Hexosaminidase contamination in bovine serum albumin: a potential problem in screening for gene carriers of Tay-Sachs disease.

one, a significant portion of CBGbound testosterone. We kindly invite Drs. Pardridge and Demers toprovide evidence to the contrary. Our observations merely indicate that there may be a moderate increase of testosterone secretion in consequence of corticotropin stimulation of the adrenals, which is reflected by total, free, and salivary testosterone concentrations, and also (probably) by the albumin-bound testosterone concentration (the latter being essentially proportional tofree testosterone). Which of the moieties of plasma testosterone corresponds more closely to bioavailable” testosterone cannot be decided on the basis of quantitative comparison with salivary testosterone concentrations for reasons that also have been given by Pardridge.